Immunohistochemical study of uterine leiomyoma in women of reproductive age
Histochemical were analyzed materials leiomyomas of the uterus removed during surgery in 245 women of reproductive age. Expression level of CD34 - a marker in the tumor tissues of the uterus was 0-1 point, the prevalence of the process - 9.6% at leiomyoma simple type; at leiomyoma with proliferative type - 3 points and 68.0%. Level of Ki-67 in stromal cells is 8.7% at a simple leiomyoma, in mitotically active leiomyoma - 59.1%. Different histological types of uterine leiomyoma are differ in neoangiogenesis, proliferation of endothelial cells in the vessel wall and the degree of uterine blood supply, resulting in differences in the mechanisms of their growth and development. Immunohistochemical features of uterine leiomyoma proliferative type are characterized by significantly different manifestations of severe stromal parenchymal relationships, violations of proliferation, apoptosis, neoangiogenesis, expression of growth factors and inflammatory processes. Reliable morphological methods for the diagnosis of leiomyoma development options is immunohistochemical methods for the determination of markers of vascular endothelial cells (CD34), proliferation (Ki-67), which are diagnostic criteria when planning a timely impact on the morphological changes in uterine leiomyoma.