Assessment of serotonin and kynurenine metabolism of tryptophan state in young persons with arterial hypotension
128 young people, including 78 people with primary arterial hypotension have been studied. The possible features of the activity of Serotonin and Kynurenine metabolism of Tryptophan have been determined. Assessment of activity of Tryptophan metabolism in patients with primary arterial hypotension performed on the content in the urine metabolite of Serotonin pathway - 5-Hydroxyindoleacetic acid (5-HIAA) and the final product of Kynurenine pathway - N-Methylnicotinamide (N-MNA). It has been established that in people with arterial hypotension there is an increase of urinary excretion of 5-Hydroxyindoleacetic acid and N-Methylnicotinamide with an increase in the ratio of N-MNA / 5-HIAA, and this point shows some prevailing exchange of Kynurenine pathway of Tryptophan metabolism and decrease in serotoninergic activity.