The influence antimicrobial coating of cateters on animals
Introduction. According to the National monitoring system of epidemiological control nosocomial infections of the US (NNIS) from 31 to 40% of all nosocomial infections constitute for catheter-associated urinary tract infection.
The aim. Determination of effect the antimicrobial coating catheters and duration antimicrobial properties of the coating.
Materials and methods. The study group were injected catheters with an antiseptic-coated. After 24 hours the infected animal depends of E.coli. We performed analysis of urine every day. The control group of animals received sterile catheters. To study the histological material used technique by Subbotin. Colouring preparations conducted with hematoxylin-eosin. Microscopic examination of histological preparations was performed using a microscope "Biolam" at 300 × magnification.
Results. In the control group of animals on the second day we noted the emergence signs of infection. Increasing edema and hyperemia of the genitals. On the 3 day, there was an unpleasant smell from the urine. Showed signs of necrosis and desquamation of epithelial plethora of vessels, small hemorrhages. The changes observed in the kidneys, ureters, urinary bladder. In the control group there was a slight hyperemia of the genitals. Changes in urine analeze not revealed.
Conclusion. Antiseptic composition have an antimicrobial effect on a wide range of microorganisms, that colonized catheters for 7 days. It create the antiseptic conditions in the catheter channel and it development of inflammation in the urinary system. It don’t cause mutagenic and degenerative changes in the organs of test animals.