Effect of various doses of complex of vitamins B2, B6, B9, B12 on biochemical values of oxidative stress in the liver of rats with hypovitaminosis - methionine hyperhomocysteinemia


  • K. P. Postovitenko
Keywords: hyperhomocysteinemia, oxidative stress, vitamin complex

Abstract

Introduction. It is known that hyperhomocysteinemia (HHC) causes oxidative stress, which is a powerful factor that leads to liver damage. Therefore it is an actual problem to develop means of correction of HHC. Hypohomocystinemic properties have vitamins В6, В9, В12 and vitamin В2.

 Aim of work is to study influence of different doses of the complex of vitamins В2, В6, В9, В12 on the levels of homocystein (HC) in plasma and indicators of oxidative stress in the liver of rats under simulated HHC.

Materials and methods. Testing was conducted in 59 nonlinear white male rats using a model with hypovitaminosis - methionine hyperhomocysteinemia (HM HHC) by keeping rats on a diet without vitamins В6, В9, В12, but enriched with L-methionine.

Results. Animals have a signifficnt level of HHC and activation of oxidative stress in the liver. Rats were treated with a complete diet and vitamin complexes I and II, containing 5 (compared with physiological) or 15 multiple doses of vitamins В2, В6, В9, В12. It was found out that only vitamin complex II completely normalized HC level in blood plasma and all indicators of oxidative stress in the liver, provoked by HM HHC.

Conclusions. The results of experiment indicate advisibility of the above complex of vitamins В2, В6, В9, В12 for HHC correction. Further study of effect of proposed vitamin complexes on other types of HHC and determining contribution of each of these vitamins to hypohomocystinemic and antioxidant action are very perspective.

Published
2017-10-27
How to Cite
Postovitenko, K. P. (2017). Effect of various doses of complex of vitamins B2, B6, B9, B12 on biochemical values of oxidative stress in the liver of rats with hypovitaminosis - methionine hyperhomocysteinemia. Reports of Morphology, 21(2), 330-335. Retrieved from https://morphology-journal.com/index.php/journal/article/view/162
Section
ORIGINAL INVESTIGATIONS