The characteristics of morphological parameters of the heart chambers in rats of different sex under sodium nitrite intoxication


  • I.O. Stakhurska
Keywords: morphometry, heart, different genders, sodium nitrite

Abstract

Introduction. One of the important medical and biological problems of nowadays is a study of pathogenesis of cardio-vascular diseases. It is widely known that ecological factors, including small doses of xenobiotics, play a considerable role in genesis of pathology, breaking the homeostasis and leading to the morbid changes. Despite the various-sided inspections of myocardium, its anatomy in animals of different sex, following sodium nitrite intoxication, is not studied enough. The analysis of morphometric, planimetric and dimensional characteristics of the heart following the toxic impact, depending on animals’ sex, provides a theoretic basement for the forward practical use of this acquirement for appreciation as well as diagnostics of diseases.

The goal of the research was a study of morphometric and dimensional parameters of heart chambers in animals of different sex under sodium nitrite intoxication.

Materials and methods.There were examined the hearts of 68 white mature sound rats of weight 185,0-200,0 g that were divided into 4 groups. The intoxication was caused by intragastric receiving of sodium nitrite in dose 5 mg/kg daily during 21 day.

Results.While the lasting acceptance of sodium nitrite, it was noticed, that the heart weight of female rats reliably (p<0,001) increased in 20,6 %, which was (1045,2±9,0) mg to (1259,8±9,3) mg. In male rats this indicator also reliably (p<0,05) increased in 25,0%, from (1095,4±9,3) mg to (1381,9±10,2) mg.

While the toxic impact on a complex organism, the weight indexes of different heart chambers changed not in the same way. During the experiment, there were found the alternations of an absolute weight of the left ventricle. This index among the group of male rats increased from (717,7±9,0) to (933,20±9,0), which made 26%. In female rats the absolute weight of the left ventricle increased from (685,2±8,7) to (848,6 ± 8,1) mg. The increment was 24 %. In the group of female rats during the experiment increased as well an absolute weight of the right ventricle from (279,8 ± 3,9) to (324,8 ± 4,0) mg, which was 16,0 %. Among male rats this parameter increased from (295,2 ± 4,2) up to (353,3 ± 4,1) mg, which made 20,0 %. The weight alternations of both left and right auricles were noted. These changes were somewhat less than the changes of weight of each ventricle.

Among female rats the size of an endocardial surface of the left ventricle during the experiment increased from (145,2 ± 2,1) to (197,2 ± 5,1) mm2, which made 36,5 %. The size of the endocardial surface of the left ventricle in male rats following intoxication reached (215,5 ± 5,4) mm2, which means that it exceed the previous morphometric parameter on 39,56 %.

In the cause of the experiment there were also found the differences between expanse parameters of the heart ventricles among rats of different sex.

Conclusion.Therefore, due to the analysis of morphometric, planimetric and dimensional indexes of myocardium of the animals that were subjected to the influence of sodium nitrite, it was indicated a prevalence of the weight of left ventricle comparatively to the right, increasing of the size of right ventricle comparing to the left, the changes of dimensional parameters of heart chambers could be observed as well. The appointed changes were more expressed between male rats than among animals of opposite sex.

Published
2017-10-27
How to Cite
Stakhurska, I. (2017). The characteristics of morphological parameters of the heart chambers in rats of different sex under sodium nitrite intoxication. Reports of Morphology, 21(2), 335-340. Retrieved from https://morphology-journal.com/index.php/journal/article/view/163
Section
ORIGINAL INVESTIGATIONS