About the possible connection of nonalcoholic fatty liver disease with hyperhomocysteinemia (review)
Nonalcoholic fatty liver disease (NAFLD) covers up to 40% of the population, in some cases - up to 75%. However, its etiology and pathogenesis are studied insufficiently. In particular, this applies to the hyperhomocysteinemia as a predictor of NAFLD progression. Experiments confirm the view that hyperhomocysteinemia is one of the pathogenetic factors of the emergence and progression of NAFLD. Hyperhomocysteinemia induces hypomethylation, protein homocysteinylation and activates oxidative stress. These phenomena are biochemical mechanisms of steatogenous action of hyperhomocysteinemia. Therefore, one of the additional measure of prevention and treatment of hepatic steatosis may be in using of hypohomocysteinemic therapy.