Neuroprotective effects of NMDA-receptor activity modulators in isch emic injury of eye (experimental and investigation)
The screening assessment of presence and expressiveness of cytoprotective effects in NMDA-receptor antagonists, namely memantine, and solutions of amantadine and magnesium sulfate at different dose ranges, was made in the model of ophthalmic ischemia-reperfusion in rats with comparative evaluation of neurodestructive process marker (NSE) activity. NSE activity de-escalation level was used as the parameter for identification of the drug-leader, for the further detailed investigation of its protective effects on retina and ophthalmic nerve; and its conditionally effective dose was specified. This drug was the solution of amantadine sulfate at dose of 5mg/kg intravenously. In the future, it is reasonable to perform detailed investigation of its efficiency in different models of ischemic injury of visual analyzer, as well as to clarify the possible mechanisms of protective action.