The influence of 4-[4-oxo-4H-quinazoline-3-il] benzoic acid on the orientation-behavior reaction of rats under the conditions of chronic immobilization stress
During the researches on the rats, it was learnt the influence of the compound PK-66 on orientation-searching and behavior activity "hypokinesia" rats in the test called open field. It was established, that 15 days hypokinesia, as powerful stress factor, has caused the oppression of the orientation-searching and behavior reaction of the rats. The course administration of the compound PK-66, under the conditions of the chronic hypodynamia, alike to bemithyl, caused the increasing of the number horizontal and pedimental movements, also the increasing of the exploratory ability in the animals. Under the conditions of the researched liquids, the amount of the defecation acts and episodes of the grooming in the hypokinesia animals decreased. The received information show us that the daily therapy of the rats by the compound Pk-66, as bemithylincrease the orientation-exploratory behavior of the animals, decreasing the level of the emotion lability.