Pathomorpho logical changes of pancreatic tissue in experimental acute pancreatitis while using antioxidants


  • V. V. Petrushenko
  • A. V. Stolyarchuk
Keywords: acute experimental pancreatitis, mexidol, ascorbic acid

Abstract

The article presents the research results of the antioxidants effectiveness in experimental acute pancreatitis. We found out that conservative therapy with antioxidants promotes a significant reduction of lipid and protein peroxidation products in the blood - malondialdehyde (on 12.4%) and protein carbonyl groups (on 39.8%) (p<0.05), and reduces inhibition of glutathione peroxidase (on 15.7%) and glutathione reductase (on 11.9%) (p<0.05) of erythrocytes. It was discovered that using of antioxidant therapy reduces acinar cells destruction, necrosis of parenchyma, inflammatory infiltration of leukocytes and macrophages, atypical reactive regeneration, and increases cell proliferation, epithelial and connective tissue structures regeneration in the pancreas.

Published
2017-10-27
How to Cite
Petrushenko, V. V., & Stolyarchuk, A. V. (2017). Pathomorpho logical changes of pancreatic tissue in experimental acute pancreatitis while using antioxidants. Reports of Morphology, 22(1), 64-68. Retrieved from https://morphology-journal.com/index.php/journal/article/view/229
Section
ORIGINAL INVESTIGATIONS