Screening cerebroprotective properties of industrial designs ampoule solution 1-adamantiloxy-3-morfolino-2-propanol hydrochloride ("Ademol") on the model of acute cerebrovascular accident by hemorrhagic type


  • N. V. Zhaboiedova
  • G. V. Zagorii
  • A. A. Khodakovskyi
Keywords: 1-adamantiloxy-3-morfolino-2-propanol hydrochloride (

Abstract

The results of screening cerebroprotective activity of the industrial design ampoule solution of 1-adamantiloxy-3- morfolino-2-propanol hydrochloride - "Ademol" compared to the reference drug, nimodipine, amantadine or magnesium sulfate on 2 models of hemorrhagic stroke, such as subarachnoid and intracerebral hemorrhage showed that studied adamantane derivatives inherent protective effect on ischemic brain. For his performance, he probably dominated solutions of magnesium sulfate, amantadine sulfate (48 hours for intra cerebral hemorrhage model) without giving with nimodipine.

Published
2017-10-27
How to Cite
Zhaboiedova, N. V., Zagorii, G. V., & Khodakovskyi, A. A. (2017). Screening cerebroprotective properties of industrial designs ampoule solution 1-adamantiloxy-3-morfolino-2-propanol hydrochloride ("Ademol") on the model of acute cerebrovascular accident by hemorrhagic type. Reports of Morphology, 22(1), 83-87. Retrieved from https://morphology-journal.com/index.php/journal/article/view/234
Section
ORIGINAL INVESTIGATIONS