Study of intracellular process cardioprotective effect derivative 3,2'- spiro-pyrrhol- 2-oxindole compound r-86 on models pituitrin-isadrinum myocardial infarction and assessment of its cytoprotective properties in the conditions of this pathology
In the context pituitrin-isadrinum myocardial infarction in the heart muscle of rats occurred deep imbalance in the exchange of adenylic nucleotides, ways of anaerobic and aerobic metabolism of glucose and formed deficit of macroergs ATP. Against this background strengthened the processes of oxidative degradation of lipids and proteins, formed the depletion of antioxidant protection, reduced content of nitric oxide precursor L-arginine and decreased total activity of NO-synthase. The use of derivative 3,2'- spiro-pyrrhol-2-oxindole compound r-86 improves energy metabolism, oxidative stress decreased the magnitude and hindered formation in a system of disorders L-arginine / NO-synthase. Thus in comparison with the reference drugs most effectively normalize of metabolic processes in the conditions of this disease contributed to the introduction of Mexidolum and, in particular, studied the original 3,2'- spiro-pyrrhol-2-oxindole. Metabolic effects of Thiotriazolin for its size significantly worse than the the compound R-86 and derived of succinic acid. For preventive and therapeutic administration of a compound R-86 reduces the cardio destructive processes in pituitrin-isadrinum myocardial infarction significantly better then mexidol.