Description of liver fibrosis in children with chronic hepatitis C at direct and indirect markers
Purpose - investigation of liver fibrosis in children with chronic hepatitis C by direct and indirect markers of fibrosis depending on the virus genotype, viral load, activity and the duration of hepatitis. 50 children with CHC aged 3-18 years were examined. Liver fibrosis was assessed by the index APRI, the level of hyaluronic acid (HA) in serum and the transforming growth factor 1 (TGF- β 1) using the method of IFA. Chronic hepatitis C in children is characterized by active fibrogenesis, as it is shown by the significant increase in concentration of HA, TGF- β 1 and index APRI in the serum of patients, in comparison with a group of healthy children. It is established that fibrogenesis in the liver in children with CHC for the studied parameters is more significant in children with genotype 1 of the virus, active hepatitis and the duration of disease more than 5 years.