Changes of analgesic effect of sodium diclofenac upon conditions of overload of the ration with fat and experimental diabetes mellitus

Abstract

With the purpose of study of the influence of experimental diabetes mellitus and a high-fat diet on the analgesic effect of sodium diclofenac (substrate of cytochrome Р4502С) the rats were fed by the ration with the increased content of fat for 4 weeks (50% of energy value of the ration against 20% in the control group) and severe diabetes mellitus was induced intraperitoneally by the injection of 70 mg/kg of Streptozotocin. At this the strengthening of the analgesic effect of sodium diclofenac because of the weakening of cytochromes - Р4502С -dependent hydroxylation to inactive metabolites was observed. Such changes in pharmacodynamics should be counted upon when the necessity arises to prescribe medications - substrate СYР2С in case of obesity and diabetes mellitus.