Prooxidant-antioxidant homeostasis, carbohydrate metabolism indicators and morphological changes in the liver after melatonine usage in experimental type 2 diabetes

Abstract

The pathogenic aspects of correcting hyperglycemia and liver damage in animals with modeled experimental type 2 diabetes were studied. It was investigated the effect of melatonin on indicators of prooxidant-antioxidant homeostasis, metabolism of carbohydrates and morpho-functional state of the liver in diabetes. It was shown that the use of the melatonine 10 mg/kg intraperitoneally for 10 days leads to inhibition of lipid peroxidation processes, enhance antioxidant protection level of the body, helps reduce blood glucose, markers of liver damage and enhance regeneration activity of hepatocytes.