Effect of amantadine hydrochloride on the activity neurodestructions processes at inferior alveolar nerve during his experimental compression-toxic iatrogenic lesions on the background of alloxan's diabetes

Abstract

Under the conditions of alloxan diabetes when the sealing materials based on resorcin-formaldehyde ("Foredent") or epoxy resin ("AH-Plus") has been enters in trepanation hole, which is located on the lower jaw projected inferior alveolar nerve, initiated destructive, degenerative changes, which is showed activity likely escalation neurodestructions marker neuron-specific enolase (NSE) and increased protein S100. Neomidantan the dose of 10 mg/kg intragastric, contributed to the reduction in the blood serum NSE activity relative to the control animal diseases in average 1,94 ("Foredent") and 1,87 times ("AH-Plus"), which has been accompanied by a parallel reduction titers S100 protein in 1.99 and 2.04 times that indicates the presence of the drug neuroprotection activity. Neomidantan (amantadine sulfate) can be used for a new purpose in the compression-toxic iatrogenic lesions of the inferior alveolar nerve on the background of diabetes which is a promising and needs clinical confirmation of its effectiveness.