Recombinant interleukin-1 receptors antagonist intracerebral administrations influence on experimental convulsive activity

Abstract

The data of experimental trials are given showing the development of anticonvulsive action in case of recombinant antagonist of interleukin-1-beta (RAIL) intracerebral administrations. RAIL intrahippocampal, intranigral and intracerebroventricular stereotactic microinjections resulted in anticonvulsive efficacy expressed mainly by seizure intensity decreasing. The most pronounced antiseizure effects were obtained after RAIL intracerebroventricular microinjection which additionally characterized by the first convulsive reactions latency increase and the number of rats with tonic-clonic seizures decrease. Relatively less effective was the severity of the RAIL-induced anticonvulsant action due to the intrahippocampal and intranigral interleukin-1 receptors blockade, respectively. The authors state the fundamental possibility of the anticonvulsive efficacy after RAIL intracerebral administrations in conditions of experimental chronic epileptogenesis.