Features of metabolic parameters, structural and functional status in patients with hypertension stage II and various body mass

Abstract

Overweight and obesity are considered to be independent predictors of the development and progression of cardiovascular disease. The aim of the study was to evaluate the features of changes in lipid, carbohydrate and fat metabolisms, nonspecific systemic inflammation activity and structural functional state of the vascular wall in patients with essential hypertension stage II, depending on body weight. The study involved 61 patients with essential hypertension stage II (28 (45.9%) women and 33 (54.1%) men), aged 30 to 64 years (average age 49.1 ± 0.9 g.). Depending on the body mass index, all patients were divided into three groups: 1st group consisted of 18 (29.5%) patients with optimal weight, 2nd 17(27.9%) patients with overweight, 3th 26 (42.6%) patients with obesity first and second degrees. In all patients with essential hypertension stage II changes in metabolic status lipid atherogenic shift, increased lipoprotein (a), C reactive protein, insulin, without changes in adiponectin levels, accompanied by increasing stiffness of the vascular wall and violation of a mobile vascular endothelial function. In the group of patients with overweight the smallest deviation parameters of metabolic, structural and functional status were recorded. Major violations were observed in patients with obesity.