Character and features of morphofunctional reactions of renal vessels in rats at chronic poisoning with acetylsalicylic acid


  • I. Ye. Herasymiuk SHEE “Ternopil Ivan Horbachevsky State Medical University of the Ministry of Healthcare of Ukraine”, Ternopil, Ukraine
  • A. H. Korytskyy SHEE “Ternopil Ivan Horbachevsky State Medical University of the Ministry of Healthcare of Ukraine”, Ternopil, Ukraine

Abstract

The prevalence and availability of aspirin-containing analgesic products makes them sources of unintentional overdose, and even suicidal admission. Therefore, the toxic effect of salicylates is an important cause of morbidity and mortality. In this case, as a rule, the target body is the kidneys. The purpose of the study was to identify the structural changes in the kidneys in the process of chronic poisoning with acetylsalicylic acid. In an experiment on rats using the histological methods of the study, it was found that chronic poisoning with acetylsalicylic acid leads to severe organ disorders in the kidneys, which are manifested in the form of congestive venous plethora with reactive ascending vasoconstriction of the arterial part of the blood route of the organ with a decrease in its throughput. At the same time there was a thickening of the walls of the vessels, which occurred both at the expense of increasing their tone, and due to edema, which was confirmed by the enlightenment of the cytoplasm of the leiomyocytes of the medial cover and an increase in the distance between the nuclei of adjacent layers of the smooth muscle cells. The endothelium of these arteries looked swollen as evidenced by the protrusion of its nuclei into the lumen of the vessels in the form of a “palisade”. Such changes can be considered as a protective reaction that partially prevents hemodynamic overload of the hemomicrocirculatory channel, known in the scientific literature as the reflex of Kitaev. However, in spite of this, in the process of chronic poisoning with acetylsalicylic acid, the complete compensation of blood circulation in the kidneys does not occur. Prolonged vasoconstriction leads to the tissue ischemia, which may be the cause of the development and progression of functional and dystrophic changes in the structural components of the organ parenchyma as a morphological substrate of renal insufficiency. Confirmation of this can be considered the changes in the glomerular apparatus found during the study, which consisted in the gradual reduction of the total area of nephrons with the simultaneous decrease in the area of capillary glomeruli. Moreover, the decrease in the area of capillary glomeruli occurred more intensively, which led to the expansion of urinary spaces. In the final stage of the experiment, the capillary glomeruli were often in collaptoid condition, their size significantly decreased, and the contours became uneven-hilly. Thus, because of the chronic poisoning by acetylsalicylic acid in the kidneys appears stagnant disturbances of the organ circulation, which cause ascending vasoconstriction in the arterial part of the blood stream of the organ, which subsequently leads to ischemia and dystrophic changes in its parenchyma.

References

[1] Alfonsova, E. V. (2013). The effect of experimental lactate acidosis on hemostasis and liver morphology. Basic research, 12(3), 417-422.

[2] Alfonsova, E. V., & Zabrodyna, L. A. (2013). Structural organization of myocardium in metabolic acidosis. Kuban Scientific Medical Herald, 1(136), 27-30.

[3] Chyka, P. A., Erdman, A. R., Christianson, G., Wax, P. M., Booze, L. L., Manoguerra, A. S. … Troutman, W. G. (2007). Salicylate poisoning: an evidence-based consensus guideline for out-of-hospital management. Clinical Toxicology Philadelphia, 45(2), 95-131. doi: 10.1080/15563650600907140

[4] Collins, E., & Turner, G. (1975). Maternal Fetal effects of regular salicylate ingestion during pregnancy. Lancet, 2, 335-339. doi: 10.1016/S0140-6736(75)92778-6

[5] Davis, J. E. (2007). Are one or two dangerous? Methyl salicylate exposure in toddlers. J. Emerg. Med., 32(1), 63-69. doi: 10.1016/j.jemermed.2006.08.009

[6] Esipova, I. K., Kaufman, O. A., & Kryuchkova, T. S. (1971). Essays on the hemodynamic reconstruction of the vascular wall. М.: Medicine.

[7] Gilman, E. A., Langman, M. J., Chengand, K. K., & Lancashire, R. J. (2000). Effect of anti-inflammatory drugs on overall risk of common cancer: case-control study in general practice research database. BMJ, 320, 1642-1646. doi: https://doi.org/10.1136/bmj.320.7250.1642

[8] Gulyeva, A. V. (2013). Determination of linear and volumetric parameters of the heart of full-term newborns in the neonatal period at hypoxic ischemic damage to the central nervous system. Ukr. J. of Clinical and Laboratory Medicine, 4, 108-112.

[9] Hernandez-Diaz, S., Varas-Lorenzo, C., & Garcia Rodriguez, L. A. (2006). Non-steroidal anti-inflammatory drugs and the risk of acute myocardial infarction. Basic Clin Pharmacol Toxicol., 98, 266-274. doi: 10.1111/j.1742-7843.2006.pto_302.x

[10] Luigi, D. L., Laura, G., Francesco, R., Carlo, B., & Domenico, C. (2001). Aspirin, exercise and pituitary hormones. Official Journal of the American College of Sports Medicine., 2029-2035.

[11] Lysenko, O. V. (2016). Acid-base state of organism, as a diagnostic, prognostic, pathogenetic marker of the formation of a cell reserve for pathological conditions. Digest. of scientific works of Shupyk NMAPE employees, 25, 623-629.

[12] Madan, R. K. & Levitt, J. (2014 Apr.). A review of toxicity from topical salicylic acid preparations. J. Am. Acad. Dermatol., 70(4), 788-792. doi: 10.1016/j.jaad.2013.12.005

[13] Marcia, L. (2007). Use of aspirin in children with cardiac disease. Pediatric Pharmacotherapy, 13(2). Retrieved from https://med.virginia.edu/pediatrics/wp-content/uploads/sites/237/2015/12/200702.pdf

[14] Mowry, J. B., Spyker, D. A., Brooks, D. E., McMillan, N., & Schauben, J. L. (2015). 2014 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 32nd Annual Report. Clin. Toxicol. (Phila), 53(10), 962-1147. doi: 10.3109/15563650.2015.1102927

[15] Mund, M. E., Gyo, C., Brüggmann, D., Quarcoo, D., & Groneberg, D. A. (2016). Acetylsalicylic acid as a potential pediatric health hazard: legislative aspects concerning accidental intoxications in the European Union. J. Occup. Med. Toxicol., 11, 32. doi: 10.1186/s12995-016-0118-5

[16] Pearlman, B. L. & Gambhir R. (2009). Salicylate intoxication: a clinical review. Postgrad Med., 121(4), 162-168. doi: 10.3810/pgm.2009.07.2041

[17] Shormanov, I. S. (2004). Vascular system of kidneys with stenosis of pulmonary trunk with different levels of compensation of blood circulation. Bulletin of experimental biology and medicine, 137(3), 332-335.

[18] Smith, S. C. Jr., Blair, S. N., Bonow, R. O., Brass, L. M., Cerqueira, M. D., Dracup, K. … Taubert, K. A. (2001). AHA/ACC guidelines for preventing heart attack and death in patients with atherosclerotic cardiovascular disease: 2001 update. A statement for healthcare professionals from the American Heart Association and the American College of Cardiology. The American College of Cardiology, 38(5), 1581-1583.

[19] Temple, A. R. (1981). Acute and chronic effects of aspirin toxicity and their treatment. Archives of Internal Medicine, 141, 364-369.

[20] Thisted, B., Krantz, T., Strøom, J., & Sørensen, M. B. (1987). Acute salicylate self-poisoning in 177 consecutive patients treated in ICU. Acta Anaesthesiol Scand., 31(4), 312-316.

[21] Yurchenko, T. M., Govorukha, T. P., Marchenko, L. M., Kondakov, I. I., & Repin, М. V. (2012). Ultrastructure and Functionality of kidneys of rats at modeling of toxic acute renal deficiency. Experimental and clinical medicine, 3, 49-53.

[22] Yvanova, L. M., & Myronenko, T. V. (2013). The role of peroxide oxidation of lipids and antioxidant protection in the pathogenesis of the irritable bowel syndrome in combination with the hypertonic disease. Ukr. J. of Clinical laboratory medicine, 4, 76-78.
Published
2018-12-27
How to Cite
Herasymiuk, I. Y., & Korytskyy, A. H. (2018). Character and features of morphofunctional reactions of renal vessels in rats at chronic poisoning with acetylsalicylic acid. Reports of Morphology, 24(2), 27-32. https://doi.org/https://doi.org/10.31393/morphology-journal-2018-24(2)-04