Comparative anatomy of the uterine tube of human and laboratory white rat females

  • M.V. Podolyuk Danylo Halytskyy National Medical University of Lviv, Lviv, Ukraine
Keywords: reproductive system, uterine tube, white rat


The world literature has accumulated a considerable amount of data to characterize the main components of the female genital system, functional relationships between them, as well as the links between this system and other systems of the organism. The relevance of the study is also due to the fact that in the structure of female infertility 6070% is occupied by a tubo-peritoneal factor. The problems associated with this pathology have been studied for more than half a century. Until now, information about the microanatomy of the fallopian tube of a human and, especially, of the female white laboratory rat is contradictory. The aim of the study was to conduct a comparative analysis of the structural organization of the uterine tube of a human and female laboratory white rat. The article and analyzes the data of research conducted on 10 sexually mature white rats in females of reproductive age. The method of preparation was used, for the study of macroanatomy of the uterine tube of females, and also standard histological methods (cuts of the wall of the fallopian tube in the thickness of 5-7 microns, stained with hematoxylin and eosin). The external structure of the fallopian tube of the female rat and man has some differences. Unlike humans, the fallopian tube of a white laboratory rat has the appearance of a thin and short tubule, spirally twisted into a compact lump. In the fallopian tube of the female white rat, it is advisable to distinguish 2 parts: the funnel and the fallopian part. The uterine part connects to the uterine horn cavity of the uterine opening of the fallopian tube, and the fallopian tube opens into the cavity of the peritoneum to the surface of the ovary by the abdominal opening of the fallopian tube. Around the funnel of the fallopian tube, its mucous membrane is gathered in folds - the fringe of the fallopian tube and the ovarian fringe (in humans - one ovarian fringe), which are attached to the ovary. The diameter of the fallopian tube of the female white rat decreases in the direction from the funnel to the uterine part. In particular, in the area of the funnel, the diameter of the fallopian tube is 0.90±0.10 mm, and the diameter of the fallopian part is 0.70±0.09 mm. The uterine tube of a laboratory white rat, like a human, has a mesentery of the fallopian tube. Both in human and in female white rat, the wall of the fallopian tube consists of three layers: the inner lining is mucous, the middle lining is muscular, the outer lining is serous. It was established that the female uterine tube of a white rat in its macroscopic structure differs from the uterine tube of a person. The microscopic structure of human and the white rat female uterine tube is rather similar and, therefore, may serve as an object of the experimental modeling of certain pathological conditions of the reproductive system.


[1] Adamyan, L. V., Kharchenko, E. I., Bragina, E. E., Murvatov, K. D., Stepanyan A. A., & Zobova A. V. (2015). Epithelium structure of the fimbrial branch of the fallopian tubes in women of reproductive age. Reproduction Problems, 21(4), 8-16.
[2] Aketayeva A. (2016). Modern view on the anatomy and function of the fallopian tubes. Clinical medicine of Kazakhstan, 40(2), 14-21. doi:10.23950/1812-2892-2016-2-14-21.
[3] Akhmedova, M. I., Khozhanazarova, S. Zh., Ashurova, F. K., & Mardonov, B. R. (2016). Morphological characteristics of intraorgan tubal vessels in experimental diabetes mellitus. Journal of Theoretical and Clinical Medicine, 1, 9-11.
[4] Asaturova. A. V, Ezhova, L. S, Fayzullina, N. M., Adamyan, L. V, Habas, G. N., & Sannikova, M. V. (2017). Expansion of secretory cells of the uterine tube epithelium in the early stages of pathogenesis serous carcinoma of the ovary. Archive of pathology, 79(3), 10-18.
[5] Bakhmet, A. A., Kuznetsova, M. A., Miroshkin, D. V., & Kupriyanov, I. E. (2015). Morphological structure of the mucous membrane of the ureter and fallopian tubes. Academic Journal of Western Siberia, 11(2), 141-142.
[6] Chen, H., Klein, R., Arnold, S., Chambers, S., & Zheng, W. (2016). Cytologic studies of the fallopian tube in patients undergoing salpingo-oophorectomy. Cancer Cell. Int., 16, 78. DOI: 10.1186/s12935-016-0354-x.
[7] Colón, E., & Carlson, J. W. (2014). Evaluation of chemotherapy after persistence of the tube after neoadjuvant chemotherapy: persistence of serous tubal intraepithelial carcinoma. Int. J. Gynecol. Pathol. 33(5), 463-469. DOI: 10.1097/PGP.0b013e3182 a142 c.2.
[8] Deel, C. D., Allen, R. A., Holman, L. L., & Zuna, R. E. (2016). Adenocarcinoma of the cervix involving the fallopian tube mucosa: report of a case. Diagn Pathol., 11, 77. DOI: 10.1186/s13000-016-0529-8.
[9] Dixon, D., Alison, R., Bach, U., Colman, K., Foley, G. L., Harleman, J. H. … Yoshida M. (2014). Nonproliferative and Proliferative Lesions of the Rat and Mouse Female Reproductive System. J. Toxicol. Pathol. 27(3-4). 1S-107S. DOI: 10.1293/tox.27.1S.
[10] Dzhadranov, E. S., Ibadullaeva, G. S., Yergazina, M. Zh., Krasnoshtanov, А. V., Krasnoshtanov, V. К., Kemelbekova, А. Қ., & Zhusip, B. P. (2016). Structural features of some internal organs of the laboratory mice of reproductive age. Bulletin of KazNMU, 4, 266-269.
[11] Dzіs, N. P. (2014). Before feeding on the reproductive function of women from a gynecologic pathology of the pilot and non-spontaneous genesis. Bulletin of Vinnitsa National Medical University, 18(1), 2, 302-306.
[12] Foti, P. V., Ognibene, N., Spadola, S., Caltabiano, R., Farina, R., Palmucci, S. ... Ettorre, G. C. (2016). Non-neoplastic diseases of the fallopian tube: MR imaging with emphasis on diffusion-weighted imaging. Insights Imaging, 7(3), 311-327. DOI: 10.1007/s13244-016-0484-7.
[13] Hua, G., Lv, X., He, C., Remmenga, S. W., Rodabough, K. J., Dong, J., & Wang, C. (2016). YAP induces high-grade serous carcinoma in fallopian tube secretory epithelial cells. Oncogene, 35(17), 2247-2265. DOI: 10.1038/onc.2015.288.
[14] Kessler, M., Fotopoulou, C., & Meyer, T. (2013). The Molecular Fingerprint of High Grade Serous Ovarian Cancer Reflects Its Fallopian Tube Origin. International Journal of Molecular Sciences, 14(4), 6571-6596. DOI: 10.3390 / ijms14046571.
[15] Kessler, M., Hoffmann, K., Brinkmann, V., Thieck, O., Jackisch, S., Toelle, B. … Meyer, T. F. (2015). The Notch and Wnt pathways regulate stemness and differentiation in human fallopian tube organoids. Nat. Commun., 6, 8989. DOI: 10.1038/ ncomms9989.
[16] Kharchenko, E. I., Adamyan, L. V., Bragina, E. E., Murvatov, K. D., Stepanyan, A. A., & Arslanian, K. N. (2012). Ultrastructural study of tubal epithelium in women of reproductive age with benign tumors and ovarian cysts. Obstetrics and gynecology, 7, 50-53.
[17] Klyuchko, S. S., Yevtushenko, V., Sokolovskiy, D. M., & Shilan, K. V. (2016). Morphological features of the lymphoid component of the sheath of the uterine tubes of the domestic market. Actual problems of medicine, 16-4 (56-2), 14-17.
[18] Lee, N. K., Choi, K. U., Han, G. J., Kwon, B. S., Song, Y. J., Suh, D. S., & Kim K. H. (2016). Pseudocarcinomatous hyperplasia of the fallopian tube mimicking tubal cancer: a radiological and pathological diagnostic challenge. J. Ovarian Res., 9, 79. DOI: 10.1186/s13048-016-0288-x.
[19] Matsumoto, H. (2017). Molecular and cellular events during blastocyst implantation in the receptive uterus: clues from mouse models. J. Reprod. Dev., 63(5), 445-454. DOI: 10.1262/jrd.2017-047.
[20] Niikura, R., Hayakawa, Y., Hirata, Y., Konishi, M., Suzuki, N., Ihara, S. … Koike, K. (2018). Distinct Chemopreventive Effects of Aspirin in Diffuse and Intestinal-Type Gastric Cancer. Cancer Prev. Res., 11(4). DOI: 10.1158/1940-6207.CAPR-17-0276.
[21] Sari, M. E., Ozdemir, O., Kadirogullari, P., Ertugrul, F. A., & Atalay, C. R. (2015). Mature Cystic Teratoma of the Fallopian Tube in a Postmenopausal Woman: A Case Report and Review of the Literature. Case Rep. Obstet. Gynecol., 583021. DOI: 10.1155/2015/583021.
[22] Teijeiro, J. M., & Marini, P. E. (2015). S100A7 in the Fallopian tube: a comparative study. Zygote, 23(2), 229-236. DOI: 10.1017/S0967199413000464.
[23] Voznesenska, T. Yu., Koleinkova, O. M., Blashkiv, T. V., Brizgina, T. M., Sukhina, V. S., & Yanchiy, R. I. (2013). Functional organ of the reproductive system in the minds of the experimental ear-numbered stem from Misha. Visnyk problems biologії і medicine, 2(100), 125-128.
[24] Wang, C., Liu, Y., Chang, C., Wu, S., Gao, J., Zhang, Y. … Deng, G. (2016). Human fallopian tube proteome shows high coverage of mesenchymal stem cells associated proteins. Biosci. Rep., 36(1). e00297. DOI: 10.1042/BSR20150220.
[25] Yuan, J., Zhao, W., Yan, M., Zhu, Q., Qin, G., Qiu, J., Zhang, J. (2015). Ulipristal Acetate Antagonizes the Inhibitory Effect of Progesterone on Ciliary Beat Frequency and Upregulates Steroid Receptor Expression Levels in Human Fallopian Tubes. Reprod. Sci., 22(12), 1516-1523. DOI: 10.1177/ 1933719115589409.
How to Cite
Podolyuk, M. (2018). Comparative anatomy of the uterine tube of human and laboratory white rat females. Reports of Morphology, 24(4), 47-52.