Morphofunctional changes in the lymphoid component of the rats prostate gland in conditions of immunostimulation

  • V.M. Evtushenko Zaporizhzhia State Medical University, Department of Histology, Cytology and Embryology, Zaporizhzhia, Ukraine
  • V.K. Syrtsov Zaporizhzhia State Medical University, Department of Histology, Cytology and Embryology, Zaporizhzhia, Ukraine
  • S.S. Popko Zaporizhzhia State Medical University, Department of Histology, Cytology and Embryology, Zaporizhzhia, Ukraine
Keywords: prostate gland, immunostimulation, lymphoid component.


To date, the state of the local immune system of the human prostate gland is not sufficiently studied, which prevents in-depth study of sexual disorders and infertility in men, as well as its common diseases: hypertrophy, adenoma, cancer. In order to study the morphological state of the lymphoid apparatus of the prostate of rats on the background of immunostimulation, 60 rat prostate glands were studied by histological, morphometric and statistical methods. Using the methods of variation statistics, we assessed the correctness of the distribution of signs for each of the obtained variation series, the average values for each attribute that was studied, standard errors and standard deviations. The reliability of differences in values between independent micrometric values with a normal distribution of signs was determined by the Student’s criterion. The paper describes the patterns of formation of the local immune system of the prostate gland in the experiment after the introduction of immunoglobulin in adult male rats Wistar line. It was revealed that in rats after administration of immunoglobulin, the formation of lymphoid structures was observed three days earlier than in intact and control rats. First appear lymphoid formations in the stroma of the prostate gland, in the blood vessels – perivascular lymphoid nodules. By the end of the first week, lymphoid structures are formed in the glandular epithelium of the prostate gland – lymphoepithelial nodules. In lymphoid structures, the content of lymphocytes in all periods exceeds the benchmarks with the maximum changes on day 7 of the study. Reactive changes in the capillary endothelium in close relationship with the restructuring of lymphoid nodules during antigenic stimulation indicate that they are redundant in providing immune homeostasis. Thus, against the background of immunostimulation, changes occur in the local immune system of the prostate gland, manifested in an increase in the number of immunocompetent cells, the formation of lymphoid nodules, and are accompanied by corresponding changes in the hemomicrocirculatory bed.


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How to Cite
Evtushenko, V., Syrtsov, V., & Popko, S. (2019). Morphofunctional changes in the lymphoid component of the rats prostate gland in conditions of immunostimulation. Reports of Morphology, 25(1), 19-24.