Characteristics of the uterine tubes in the fetal period: topographic and morphometric parallels
Topicality of the study is stipulated by the importance of objective data for medicine concerning formation of the structure and topographic-anatomical interrelations of the uterine tubes with adjacent organs and structures during the prenatal period of human ontogenesis. Objective: to find and compare tendencies of changes of the uterine tube morphologic parameters in the two groups of fetuses remote in time, and determine age peculiarities of their topography during perinatal period of development. The experimental material (specimens of fetuses) was divided into two groups: І group – 35 specimens of fetuses deceased during 2017-2019; ІІ group – 105 specimens of fetuses taken from the Museum of the Departments of Anatomy, Clinical Anatomy and Operative Surgery at Higher State Educational Establishment of Ukraine “Bukovinian State Medical University”, collected during 1970-1990. Every group was subdivided into 7 subgroups according to 10 months of the fetal period of development (from the 4th to the 10th months). The results obtained were statistically processed in the licensed statistical package “Statistica 6.0” using nonparametric methods to evaluate the results. Regular changes in the topography of the right and left uterine tubes, changes in their shape and histological structure are observed. Both uterine tubes were found to occupy an ascending position in thirty cases out of sixty examined specimens of early fetuses (4-6 months of age). In twenty cases one uterine tube was found to be in an ascending position, and in ten cases both uterine tubes were placed practically horizontally. The study of uterine tube morphogenesis in 7-month fetuses found that the structure and topography of the uterine tubes in different age periods differ. In two 7-month fetuses the uterine tubes were found to be in an ascending position, in eight cases one uterine tube (the left one – in six cases out of eight) was in a horizontal position, and in ten cases two uterine tubes were directed practically horizontally. During the 8th month of the antenatal development one uterine tube was found to be in an ascending position out of eight cases; in ten cases both uterine tubes were in the position close to a horizontal one; and in two cases the left uterine tube was in a descending position. In 9-month fetuses both uterine tubes were found to be in a horizontal position in twelve cases, in eight cases one of the uterine tubes was in the position close to a descending one. In fourteen fetuses 10 months of development one uterine tube was in a descending position, and only in six cases both uterine tubes were located horizontally. The length of the uterine tubes of 4-7-month fetuses deceased during 2017-2019 was not found to differ reliably. Similar regularity was found in the group of fetuses aged from 9 to 10 months. The length of the uterine tubes of the archival specimens increases reliably every two months. In this group of fetuses the parameters of the uterine tube length aged from 9 to 10 months were found to differ reliably contrary to the length of the uterine tubes in the group of modern specimens of a similar age. Comparison of dynamics in changes of the uterine tube length in the two groups of fetuses remote in time showed that within the frame of one group differences in the morphometric parameters between the right and left uterine tubes are not considerable. Therefore, the study of peculiarities in the structure of the uterine tubes at every stage of the perinatal period found certain peculiarities and regularities of their development.
 Acién, P., & Acién, M. (2016). Diagnostic imaging and cataloguing of female genital malformations. Insights into Imaging, 7(5), 713-726. doi: 10.1007/s13244-016-0515-4
 Ando, H., Watanabe, Y., Ogawa, M., Tamura, H., Deguchi, T., Ikeda, K., … Adachi, S. (2017). Mesonephric adenocarcinoma of the uterine corpus with intracystic growth completely confined to the myometrium: a case report and literature review. Diagnostic Pathology, 12(1), 63. doi: 10.1186/s13000-017-0655-y
 Akhtemiichuk, Yu. T., & Piatnytska, T. V. (2010). Histotopography of the uterine tubes in human fetuses. Clinical Anatomy and Operative Surgery, 9(4), 50-54.
 Akhtemiichuk, Yu. T., Piatnytska, T. V., & Manchulenko, D. G. (2012). Morphogenesis of the uterine tubes during prenatal period of human ontogenesis. Theses published in the Materials of the 3rd Scientific Symposium “Anatomical-Surgical Aspects of Pediatric Gastroenterology”, Chernivtsi. Chernivtsi: BSMU.
 Akhtemiichuk, Yu. T., Piatnytska, T. V., & Marchuk, V. F. (2011). Microstructure of the uterine tubes during the prenatal period of ontogenesis. Theses published in the Materials of the Scientific-Practical Conference: “Morphological Aspects of Microcirculation in the Norm and Pathology”. Ternopil: Ukrmedknyha.
 Banul, B. Yu., & Marchuk, F. D. (2013). Development of the uterine tubes at the end of the fetal period of human ontogenesis. Bukovinian Medical Herald, 18(2), 206-208.
 Banul, B. Yu., Marchuk, F. D., & Liutyk, M. D. (2013). Development of the uterine tubes at the end of the pre-fetal and early fetal periods of human ontogenesis. Theses published in the Materials of the 94th Final Scientific Conference of the Professional and Teaching Staff of Bukovinian State Medical University, Chernivtsi. Chernivtsi: BSMU.
 Caliskan, S. (2017). Bilateral ureteral duplication of complete left and incomplete right side with lower pole kidney stone. Journal of the College of Physicians and Surgeons, 27(3), 65-66. PMID: 28302252
 Chapel, D. B., Joseph, N. M., Krausz, T., & Lastra, R. R. (2018). An Ovarian Adenocarcinoma With Combined Low-grade Serous and Mesonephric Morphologies Suggests a Müllerian Origin for Some Mesonephric Carcinomas. International Journal of Gynecological Pathology, 37(5), 448-459. doi: 10.1097/PGP.0000000000000444
 Darcy, D. G., Yao-Cohen, M., Olson, T. R., & Downie, S. A. (2017). Unilateral complete agenesis of mesonephric duct derivatives in an 82-year-old male cadaver: embryology, anatomy and clinical considerations. Urology Case Reports, 15, 20-22. doi: 10.1016/j.eucr.2017.06.003
 Davidson, E. R. W., & Barber, M. D. (2017). A gartner duct cyst masquerading as anterior vaginal prolapse. Obstetrics & Gynecology, 130(5), 1039-1041. doi: 10.1097/AOG.0000000000002315
 George, C., & Berge, L. R. (2002). Hypothesis Testing. Statistical Inference. Second Edition. Pacific Grove, CA: Duxbury.
 Jin, Z. W., Abe, H., Hinata, N., Li, X. W., Murakami, G., & Rodríguez-Vázquez, J. F. (2016). Descent of mesonephric duct to the final position of the vas deferens in human embryo and fetus. Anatomy & Cell Biology, 49(4), 231-240. doi: 10.5115/acb.2016.49.4.231
 Khmara, T. V., & Voitenko, S. G. (1994). To the issue of development of the human uterine tubes. Theses published in the Materials of the Conference “Scientists of Bukovyna – to the Public Health Care”, Chernivtsi: [w.p.].
 Ludwig, K. S. (1993). The development of the caudal ligaments of the mesonephros and of the gonads: a contribution to the development of the human gubernaculum (Hunteri). Anatomy and Embryology, 88, 571-577. doi: 10.1007/bf00187012
 Mirkovic, J., McFarland, M., Garcia, E., Sholl, L. M., Lindeman, N., MacConaill, L., … & Howitt, B. E. (2018). Targeted genomic profiling reveals recurrent kras mutations in mesonephric-like adenocarcinomas of the female genital tract. The American Journal of Surgical Pathology, 42(2), 227-233. doi: 10.1097/PAS.0000000000000958
 Moisiuk, D. V., Syniuk, O. S., & Zayats, V. V. (2006). Peculiarities of the uterine tube structure. Theses published in the Materials of the IV International Scientific-Practical Conference of Students and Young Scientists, Uzhgorod. Uzhgorod: Grazhda.
 Piantnytska, T. V. (2010). Formation of the uterine tubes during the pre-fetal period of ontogenesis. Theses published in the Materials of the Scientific-Practical Conference devoted to the 70th anniversary of the Honoured Scientist and Technician of Ukraine, Professor Ya.I. Fedoniuk “Topical Issues of Morphology”, Ternopil. Ternopil: Ukrmedknyha.
 Pronyayev, V. I., Svistonyuk, I. U., & Akhtemiychuk, Yu. T. (1995). Changes in the length of embryos depending on their age, type and concentration of fixatives. Thesis in materials of “International Congress on Integrative Anthropology”. Ternopíl': [w.p].
 Puljiz, M., Danolić, D., Kostić, L., Alvir, I., Tomica, D., Mamić, I., & Balja, M. P. (2016). Mesonephric adenocarcinoma of endocervix with lobular mesonephric hyperplasia: case report. Acta Clinica Croatica, 55(2), 326-330. doi: 10.20471/acc.2016.55.02.22
 Roder, D., Davy, M., Selva-Nayagam, S., Paramasivam, S., Adams, J., Keefe, D., … Oehler, M. K. (2018). Exploring the added value of hospital-registry data for showing local service outcomes: cancers of the ovary, fallopian tube and peritoneum. BMJ Open, 9(2), e024036. doi: 10.1136/bmjopen-2018-024036
 Shelamova, M. A., Insarova, N. I., & Leshchenko, V. H. (2010). Statistical analysis of medical-biological data using Excel program. Teaching-Methodical Manual. Minsk: BSMU.
 Singh, K., Sung, C. J., Lawrence, W. D., & Quddus, M. R. (2017). Testosterone-induced "virilization" of mesonephric duct remnants and cervical squamous epithelium in female-to-male transgenders: a report of 3 cases. The International Journal of Gynecological Pathology, 36(4), 328-333. doi: 10.1097/PGP.0000000000000333
 Tiwari, C., Shah, H., Desale, J., & Waghmare, M. (2017). Neonatal gartner duct cyst: two case reports and literature review. Developmental Period Medicine, 21(1), 35-37. PMID: 28551690
 Voitenko, S. G. (1996). Topography of the uterine tubes during the fetal period of human ontogenesis. Theses published in the Materials of the Scientific Conference “Topical Issues of Morphogenesis”, Chernivtsi. Chernivtsi: [w.p.].
 Yeo, M. K., Choi, S. Y., Kim, M., Kim, K. H., & Suh, K. S. (2016). Malignant mesonephric tumor of the cervix with an initial manifestation as pulmonary metastasis: case report and review of the literature. European journal of gynaecological oncology, 37(2), 270-277. PMID: 27172762
This work is licensed under a Creative Commons Attribution 4.0 International License.