Structural organization of the ileum of laboratory animals in normal and in a comparative view aspect


  • M.I. Sydorenko Ukrainian Medical Dental Academy, Department of Clinical Anatomy and Operativ Surgery, Poltava, Ukraine
Keywords: ileum, ileum, exocrinocytes, endocrinocytes, lymphocytes, arterioles, capillaries, venules.

Abstract

In recent decades, diseases of the digestive system that require immediate, both therapeutic and surgical treatment, have become widespread, and it is therefore a natural task to find new and optimize existing technologies and methods for correcting the above-mentioned nosologies. Preclinical studies of such developments are conducted exclusively on laboratory animals and knowledge of the morphological features of their structure for further comparison with the morphology of similar human organs is an urgent task of modern medical and biological science. The purpose of the study was to study the structural organization of the ileum of rabbits in comparative species and to obtain control data on its morphological features. Adequate research methods were used in the work according to the set goal, namely: histological, histochemical, electron microscopic, morphometric and statistical and biopsies of the ileum of 10 rabbits were studied. The correctness of the distribution of traits by each of the variations obtained, the average values for each trait studied, standard errors and standard deviations were evaluated. The significance of the difference of values between independent micrometric values in the normal distribution of features was determined by Student’s criterion. The paper describes the main structural components of the ileum of rabbits and compared with similar structures of the human ileum. The ileum of rabbits, as in humans, has been determined to have four membranes: mucous, submucosal, muscular and serous. The mucous membrane is constructed from the epithelial layer, which is located on the basement membrane and the muscular plate and contains cellular elements (exocrinocytes, enterocytes of various kinds, elements of the diffuse endocrine system associated with the mucous membrane, intraepithelial lymphocytes), blood and lymphatic vessels and nerve endings. The submucosa is composed of loose fibrous connective tissue, which contains collagen and reticular fibers, elements of diffuse lymphoid tissue, blood vessels, and nerve endings. The muscular and serous membranes are constructed in the same way as in the human ileum. Thus, after the study, it was determined that the morphological organization of the ileum of rabbits at the optical and electron microscopic levels has general patterns of structure similar to those in the ileum of the person.

References

[1] Antonyuk, O. P. (2016). Features of organogenesis digestive system of the human. Bulletin of problems in biology and medicine, 4(133), 279-284.

[2] Bilash, S. M. (2013). [Influence of Cryopreserved Placenta on the Morphofunctional State of Stomach Pyloric Glands’ Exocri-nocytes at Acute Inflammation Processes. Bulletin of problems in biology and medicine, 2(99), 224-227.

[3] Cardamone, C., Parente, R., De Feo, G., & Triggiani, M. (2016). Mast cells as effector cells of innate immunity and regulators of adaptive immunity. Immunology letters, 178, 10-14. doi: 10.1016/j.imlet.2016.07.003

[4] Gomes, J. R., Ayub, L. C., dos Reis, C. A., Machado, M. J., da Silva, J., Omar, N. F., & de Miranda Soares, M. A. (2017). Goblet cells and intestinal alkaline phosphatase expression (IAP) during the development of the rat small intestine. Acta histochemica, 119(1), 71-77. doi: 10.1016/j.acthis.2016.11.010

[5] Hryn, V. H., Kostylenko, Y. P., Yushchenko, Y. P., Ryabushko, M. M., & Lavrenko, D. O. (2018). Comparative histological structure of the gastrointestinal mucosa in human and white rat: a bibliographic analysis. Wiadomosci lekarskie (Warsaw, Poland: 1960), 7(71), 1398-1403. PMID: 30448817

[6] Hryn, V. H., Kostylenko, Y. P., Yushchenko, Y. P., Lavrenko, A. V., & Ryabushko, O. B. (2018). General comparative anatomy of human and white rat digestive systems: a bibliographic analysis. Wiadomosci lekarskie (Warsaw, Poland: 1960), 71(8), 1599-1602. PMID: 30684346

[7] Hryn, V. H., Kostylenko, Y. P., & Yachmin’ A. I. (2019). Features of white rats stomach аnatomical structure. World of medicine and biology, 1(67), 133-137. doi: 10.26724/2079-8334-2019-1-67-133

[8] Hryn, V. H., Kostylenko, Y. P., Bilash, V. P., & Tarasenko, Y. A. (2019). Features of angioarchitecture of the albino rats stomach and small intestine. Wiadomosci lekarskie (Warsaw, Poland: 1960), 3(72), 311-317. PMID: 31050973

[9] Hryn, V. H., Kostylenko, Y. P., Bilash, V. P., & Ryabushko, O. B. (2019). Microscopic structure of albino rats’ small intestine. Wiadomosci lekarskie (Warsaw, Poland: 1960), 5(72), 733-738. PMID: 31175762

[10] Hryn V. Kostylenko Y., Korchan, N., & Lavrenko, D. (2019). Structural form of the follicle-associated epithelium of Рeyers’ patches of the albino rats’ small intestine. Georgian medical news, 9(294), 118-123. PMID: 31687962

[11] Kolesnik, O. O. (2006). Treatment of patients with stromal tumors of the colon (GIST). Oncology, 3(8), 272-277.

[12] Nawaz, M., Shah, N., Zanetti, B. R., Maugeri, M., Silvestre, R. N., Fatima, F., ... & Valadi, H. (2018). Extracellular vesicles and matrix remodeling enzymes: the emerging roles in extracellular matrix remodeling, progression of diseases and tissue repair. Cells, 7(10), 167. doi: 10.3390/cells7100167

[13] Lutsyk, O. D., Chaykovskyy, Yu. B. [Ed.] (2018). Histology. Cytology. Embryology: a textbook. Vinnytsia: Nova knyha.

[14] Omar, N. F., Gomes, J. R., Neves, J. D. S., & Novaes, P. D. (2018). Effects of loss of occlusal contact on the expression of matrix metalloproteinase‐2, membrane type 1‐MMP, tissue inhibitor of the mmP‐2, eruption rate, organization and resistance of collagen fibers of the rat incisor periodontal ligament. Journal of periodontal research, 53(1), 40–46. doi: 10.1111/jre.12484

[15] Phillips, T. M., Fadia, M., Lea-Henry, T. N., Smiles, J., Walters, G. D., & Jiang, S. H. (2017). mmP2 and mmP9 associate with crescentic glomerulonephritis. Clinical kidney journal, 10(2), 215-220. doi: 10.1093/ckj/sfw111

[16] Pronina, O. M., Koptev, M. M., Bilash, S. M., & Yeroshenko, G. A. (2018). Response of hemomicrocirculatory bed of internal organs on various external factors exposure based on the morphological research data. World of medicine and biology, 1(63), 153-157. doi: 10.26.724/2079-8334-2018-1-63-153-157

[17] Ryngach, N. О., & Keretsman, A. О. (2015). Diseases of the digestive system: historical parallels changes in classification andepidemiological situation. Family medicine, 4, 137-141.

[18] Xu, H., Bin, N. R., & Sugita, S. (2018). Diverse exocytic pathways for mast cell mediators. Biochemical Society Transactions, 46(2), 235–247. doi: 10.1042/BST20170450
Published
2019-06-26
How to Cite
Sydorenko, M. (2019). Structural organization of the ileum of laboratory animals in normal and in a comparative view aspect. Reports of Morphology, 25(2), 72-77. https://doi.org/https://doi.org/10.31393/morphology-journal-2019-25(2)-09