Morphological changes in the conditions of adrenaline myocardial dystrophy against the background of the introduction of the compound PC-66 and amiodarone to rats


  • O.V. Dzhyhaliuk National Pirogov Memorial Medical University, Vinnytsya, Ukraine
  • D.A. Lysenko National Pirogov Memorial Medical University, Vinnytsya, Ukraine
  • D.G. Smolko National Pirogov Memorial Medical University, Vinnytsya, Ukraine
  • I.M. Kyrychenko National Pirogov Memorial Medical University, Vinnytsya, Ukraine
  • S.V. Prokopenko National Pirogov Memorial Medical University, Vinnytsya, Ukraine
Keywords: cardioprotection, PC-66, amiodarone, myocardium, morphology.

Abstract

Adrenaline damage to the myocardium is an important element in the pathogenesis of myocardial infarction in humans. Despite the use of modern methods of treatment of myocardial infarction, the issue of cardioprotection of reperfusion myocardial damage remains open. Promising in this direction is the use of quinazolone derivatives, which have already shown cardioprotective properties in other models of myocardial infarction. The aim of the study was to establish morphological changes in the conditions of adrenaline myocardiodystrophy (AMD) against the background of the introduction of the compound PC-66 and amiodarone in rats. The study was performed on 100 nonlinear rats of both sexes weighing 165-220 g, divided into four groups of 25 animals each: 1 – intact rats; 2 – rats with a model of adrenaline myocardial infarction without treatment (control); 3 – rats with AMD treated with amiodarone (10 mg/kg, intraperitoneally); 4 – rats with AMD treated with compound PC-66 (10 mg/kg, intraperitoneally). It was found that control rats under conditions of cardiotoxic dose of adrenaline in the left ventricular myocardium for up to 8 days of the experiment does not fully restore the myocardial structure, dystrophic and necrobiotic changes were found in both cardiomyocytes and walls of vessels of a blood microcirculatory channel of a myocardium. Course intraperitoneal administration to rats of the compound PC-66 in the conditions of adrenaline myocardial infarction as well as amiodarone, contributes to the attenuation of signs of dystrophic and destructive processes. The degree of protective effect on the myocardium under conditions of cardiotoxic dose of adrenaline compound PC-66 was not lower to the reference drug – amiodarone. Thus, it is morphologically confirmed that in adrenaline myocardial infarction the compound PC-66, similar to the action of amiodarone, has a cardioprotective effect.

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Published
2020-05-22
How to Cite
Dzhyhaliuk, O., Lysenko, D., Smolko, D., Kyrychenko, I., & Prokopenko, S. (2020). Morphological changes in the conditions of adrenaline myocardial dystrophy against the background of the introduction of the compound PC-66 and amiodarone to rats. Reports of Morphology, 26(1), 48-53. https://doi.org/https://doi.org/10.31393/morphology-journal-2020-26(1)-07