Peculiarities of gynecological history and reproductive status of women with psycho-emotional disorders related to prenatal stress

  • I.V. Semenenko Zaporizhzhya State Medical University, Zaporizhzhya, Ukraine
Keywords: infertility, prenatal stress, ovarian reserve, in vitro fertilization.


Persistent anovulation, menstrual disorders lead to the development of endocrine-dependent gynecological diseases, one of the manifestations of which is primary infertility. The aim of the study: to assess the clinical features of history and reproductive status in women with psycho-emotional disorders associated with prenatal stress. The study involved 120 patients, 80 of whom suffered prenatal stress: 1 – the main group, which is divided into 1A subgroup – women who underwent in vitro fertilization, and 1B subgroup – women who did not undergo in vitro fertilization. For comparison, a 2 – control group of 40 women without prenatal stress with exclusively tubal factor of infertility, in which the parameters of the functional state of the reproductive system corresponded to the normal ovarian reserve. The age of patients ranged from 22 to 45 years. Complaints, anamnesis of disease and life, gynecological anamnesis, level of education were studied in all patients, the causes of infertility were assessed. The results of the study were processed using the statistical package of the licensed program “STATISTICA® for Windows 13.0”. The normality of the distribution of indicators was established by the Shapiro-Wilk criterion. Descriptive statistics are presented as the arithmetic mean and standard deviation of M±SD or the median and quartile interval Me (Q1-Q2) depending on the distribution of the trait. It was found that in place of residence, social status, the presence of bad habits, gynecological history of infertile patients in in vitro fertilization programs do not differ from healthy women with tubal-peritoneal factor infertility. There was a significant difference between the indicators of the nature of the menstrual cycle in the comparison groups. It has been found that a menstrual cycle of less than 23 days is a predictor of reduced functional activity of the hypothalamic-pituitary-ovarian axis in women. Analysis of hormonal regulation of reproductive function of the examined groups of women found the prevalence of FSH in the main group over the control (9,611±0,212 vs. 6,221±0,113 mMod/ml, respectively, (p<0.05), and the level of TSH was not differences between comparison groups. We proposed to identify 3 states of ovarian reserve - normal, low and extremely low for women with a history of infertility and prenatal stress. Conclusion: timely comprehensive assessment of the endocrine system, ovarian status in relation to the state of regulatory mechanisms of psychoemotional adaptation of women with infertility associated with prenatal stress, which we studied, requires a partial revision of approaches to this group of patients and timely use of in vitro extracorporeal the effectiveness of infertility treatment.


[1] Bobrov, A.E. (2017). Проблема психосоматических соотношений и некоторые методологические вопросы психопатологии [The problem of psychosomatic relations and some methodological issues of psychopathology]. Социальная и клиническая психиатрия – Social and Clinical Psychiatry, 27(1), 98-103.
[2] Dudina, O.O., & Gaborets, Y.Y. (2017). Репродуктивне здоров’я як чинник фертильності жінок і якості здоров’я народжуваних поколінь [Reproductive health as a factor of women’s fertility and quality of health of nascent generations]. Економіка і право охорони здоров’я – Economics and Law of Health Care, 6(2), 28-35.
[3] Zhylka, N.J., Myronjuk, I.S., & Slabkyi, G.O. (2018). Характеристика деяких показників репродуктивного здоров’я жіночого населення України [Characteristics of Some Indicators of Reproductive Health of the Female Population of Ukraine]. Медичні новини – Wiadomości Lekarskie, LXXI(9), 1803-1808.
[4] Zhuk S.I., & Schurevskaya O.D. (2016). МикроРНК 210, 21 – современные маркеры стресса у беременных [MicroRNA 210, 21 – modern stress marker in pregnant]. Репродуктивное здоровье. Восточная Европа – Reproductive Health. Eastern Europe, 5, 615-622.
[5] Kalinichenko, D.O. (2019). Кількісна оцінка репродуктивного потенціалу жінок раннього фертильного віку [Quantitative assessment of the reproductive potential of women of early fertile age]. Довкілля та здоров’я – Environment and Health, (3(92)), 11-16.
[6] Korolovich, O.V. (2018). Детермінанти психогенного безпліддя: глибинний погляд на проблему [Determinants of psychogenic infertility: an in-depth look at the problem]. Психологічний журнал – Psychological Journal, 4(8),18, 76-85.
[7] Kaminsky, A.V. (2018). Біоелектрична активність кори головного мозку у пацієнтів з циклами допоміжних репродуктивних технологій [Bioelectric activity of cerebral cortex in patients with cycles of assisted reproductive technologies]. Журнал освіти, здоров’я та спорту – Journal of Education, Health and Sport, 8(7), 445-452. doi:
[8] Tatarchuk, T.F. (2013). Ефективність застосування препаратів, що надають дофаминергическу дію, в комплексній терапії дисгормональної стрес-індукованої патології [The effectiveness of drugs that have dopaminergic action in the treatment of dyshormonal stress-induced pathology]. Репродуктивна ендокринологія – Reproductive endocrinology, 3, 90-94.
[9] Shevchuk, P.E. (2015). Реконструкція структури народжених за черговістю народження та віком матері [Reconstruction of the structure of births according to the order of birth and mother’s age]. Демографія та соціальна економіка – Demography and Social Economy, 23(1), 113-125.
[10] Bennett, L.R., & de Kok, B. (2018). Reproductive Desires and Disappointment. Medical Anthropology, 37(2), 91-100. doi: 10.1080/01459740.2017.1416609
[11] Duhig, K., Chappell, L.C., & Shennan, A.H. (2016). Oxidative stress in pregnancy and reproduction. Obstetric Medicine, 9(3), 113-116.
[12] Elwenspoek, M.M.C., Kuehn, A., Muller, C.P., & Turner, J.D. (2017). The effects of early life adversity on the immune system. Psychoneuroendocrinology, 82, 140-154. doi: 10.1016/j.psyneuen.2017.05.012
[13] Gareri, P., Castagna, A., Cotroneo, A.M., Putignano, S., De Sarro, G., & Bruni, A.C. (2015). The role of citicoline in cognitive impairment: pharmacological characteristics, possible advantages, and doubts for an old drug with new perspectives. Clin. Interv. Aging, 10, 1421-1429. doi: 10.2147/CIA.S87886
[14] Gruzieva, T.S., Diachuk, M.D., Inshakova, H.V., & Zamkevych, V.B. (2019). Modern Demographic Trends in Ukraine as a Ground for Realization of Prevention Strategies. Wiadomości Lekarskie, 72(10), 2033-2039. PMID: 31983148
[15] Hryshchenko, M.H., Luts’kyy, A.S., & Parashchuk, V.Y. (2017). Оцінка ефективності екстракорпорального запліднення після перенесення вітрифікованих бластоцист у природному циклі та із застосуванням замісної гормональної терапії [Evaluation of the effectiveness of in vitro fertilization after the transfer of vitrified blastocysts in the natural cycle and with the use of hormone replacement therapy]. Міжнародний медичний журнал – International Medical Journal, 23(4), 42-46.
[16] Lee, Y., Oh, J.S., Chung, S.J., Lee, J.J., Chung, S.J., Moon, H. … Sohn, Y.H. (2018). The presence of depression in de novo Parkinson’s disease reflects poor motor compensation. PLoS ONE. 13(9). 1-10.
[17] Li, Y.H., & Marren, A. (2018). Recurrent Pregnancy Loss: A Summary of International EvidenceBased Guidelines and Practice. Aust. J. Gen. Pract., 47(7), 432-436. doi: 10.31128/AJGP-01-18-4459
[18] Lubinsky, M. (2018). Evolutionary Justifications for Human Reproductive Limitations. J. Assist. Reprod. Genet., 35(12), 2133-2139. doi: 10.1007/s10815-018-1285-3
[19] Malak, A.L.S.B., Vasconcellos, L.F., Pereira, J.S., Greca, D.V., Cruz, M., Alves, H.V.D. … Charchat-Fichman, H. (2017). Symptoms of depression in patients with mild cognitive impairment in Parkinson’s disease. Dement Neuropsychol., 11(2), 145-153. doi: 10.1590/1980-57642016dn11-020007
[20] Nicoloro-Santa, B.J.M., Lobel, M., Bocca, S., Stelling, J.R., & Pastore, L.M. (2017). Psychological and emotional concomitants of infertility diagnosis in women with diminished ovarian reserve or anatomical cause of infertility. Fertil. Steril., 108(1), 161-167. doi: 10.1016/j.fertnstert.2017.05.008
[21] Panico, A., Messina, G., Lupoli, G.A., Lupoli, R., Cacciapuoti, M., Moscatelli, F. … Lupoli, G. (2017). Quality of life in overweight (obese) andnormal – weight women with polycystic ovary syndrome. Patient Prefer Adherence, 11, 423-429. doi: 10.2147/PPA.S119180
[22] Pinar, M.H., Gibbins, K., He, M., Kostadinov, S., & Silver, R. (2018). Early Pregnancy Losses: Review of Nomenclature, Histopathology, and Possible Etiologies. Fetal Pediatric Pathology 37(3), 191-209. doi: 10.1080/15513815.2018.1455775
[23] Plana-Ripoll, O., Li, J., Kesmodel, U.S., Olsen, J., Parner, E., & Basso, O. (2016). Maternal stress before and during pregnancy and subsequent infertility in daughters: a nationwide population-based cohort study. Hum. Reprod., 31(2), 454-462. doi: 10.1093/humrep/dev309
[24] Simmons, A.D. (2018). Parkinson’s Disease. In: D.Rakel (Ed.), Integrative Medicine (Fourth Edition). Philadelphia, PA: Elsevier.
[25] Skorvanek, M., Martinez-Martin, P., Kovacs, N., Rodriguez-Violante, M., Corvol, J., Taba, P. … Stebbins, G.T. (2017). Differences in MDS-UPDRS Scores Based on Hoehn and Yahr Stage and Disease Duration. Movement Disorders Clinical Practice, 4(4), 536-544. doi: 10.1002/mdc3.12476
[26] Yusuf, L. (2016). Depression, anxiety and stress among female patients of infertility; a case control study. Pak. J. Med. Sci., 32(6), P.1340-1343. doi: 10.12669/pjms.326.10828
How to Cite
Semenenko, I. (2021). Peculiarities of gynecological history and reproductive status of women with psycho-emotional disorders related to prenatal stress. Reports of Morphology, 27(3), 42-48.