Discriminant models of the possibility of benign nevi occurrence and features in men depending on the characteristics of anthropo-somatotypological indicators

Keywords: skin diseases, benign nevi, anthropometric indicators, body circumference, transverse body dimensions, skinfold thickness, somatotypical indicators, Ukrainian men, discriminant models.

Abstract

The multifactorial nature of the origin and development of nevi is the subject of debate so far. One way to understand this process and get an answer to this question is to use a constitutional method of research. The purpose of the study is to build and analyze discriminant models of benign nevi occurrence possibility in men depending on the characteristics of the structure and size of the body. For Ukrainian men aged 22 to 35 years with benign nevi (34 with melanocyte benign simple nevi; 27 with melanocyte benign dysplastic nevi; 14 with melanocyte benign congenital nevi; 17 with nonmelanocyte benign nevus) determined anthropometric indicators according to the scheme of Bunak V. V. (1941), components of the somatotype according to the Heath-Carter scheme (1990), as well as indicators of the component composition of body weight according to Matejko formulas (1921). The control group consisted of anthropometric and somatotypological indicators of 82 practically healthy men of the same age group selected from the data bank of the Research Center of National Pirogov Memorial Medical University, Vinnytsya. Discriminant analysis was performed in the licensed statistical package “Statistica 5.5”. With the help of discriminant analysis, reliable models of the possibility of benign nevi depending on the characteristics of anthropometric and somatotypological indicators are built. It was found that healthy and patients with benign nevi of men can reliably interpret the obtained classification indicators between healthy and sick, and between patients with melanocyte simple or dysplastic nevi and other groups of benign nevi (discriminant function covers 75.7 % of cases; Wilks' Lambda statistics=0.125; р<0.001). Between groups of benign nevi, reliable interpretation of the obtained classification indicators is possible only between patients with melanocyte simple or dysplastic nevi and melanocyte congenital or non-melanocyte nevi (discriminant function covers 48.4 % of cases; Wilks' Lambda statistics=0.662; р<0.001), however, the totality of all anthropological variables has little discrimination. The models of healthy and sick men include the skinfold thickness (42.8 %), girth sizes (28.6 %), shoulder width and endomorphic component of the somatotype (14.3 % each); and among men with benign nevi, only girth sizes of the body. The greatest contribution to discrimination in models of healthy and sick men is made by the circumference of the forearm at the top, the width of the shoulders and the skinfold thickness on the side; and among patients with benign nevi – chest girth on inspiration. The obtained results indicate a significant influence of environmental factors on the occurrence of benign nevi.

References

Ali, B. M., & Ahmed, H. A. (2018). Epidemiology of Non-Melanoma Skin Cancer Patients Attending at Hiwa Hospital in Sulaimani City, Iraq. Kurdistan Journal of Applied Research, 3(2), 44-48. doi: 10.24017/science.2018.2.7

Alikhan, A., Ibrahimi, O. A., & Eisen, D. B. (2012). Congenital melanocytic nevi: where are we now?: part I. Clinical presentation, epidemiology, pathogenesis, histology, malignant transformation, and neurocutaneous melanosis. Journal of the American Academy of Dermatology, 67(4), 495.e1-495.e17. doi: 10.1016/j.jaad.2012.06.023

Caccavale, S., Calabrese, G., Mattiello, E., Broganelli, P., Ramondetta, A., Pieretti, G., ... & Argenziano, G. (2021). Cutaneous melanoma arising in congenital melanocytic nevus: a retrospective observational study. Dermatology, 237(3), 473-478. doi: 10.1159/000510221

Chan, A. A., Noguti, J., Pak, Y., Qi, L., Caan, B., Going, S., ... & Lee, D. J. (2019). Interaction of body mass index or waist‐to‐hip ratio and sun exposure associated with nonmelanoma skin cancer: A prospective study from the Women’s Health Initiative. Cancer, 125(7), 1133-1142. doi: 10.1002/cncr.31810

Cote, D. J., Downer, M. K., Smith, T. R., Smith-Warner, S. A., Egan, K. M., & Stampfer, M. J. (2018). Height, waist circumference, body mass index, and body somatotype across the life course and risk of glioma. Cancer Causes & Control, 29(8), 707-719. doi: 10.1007/s10552-018-1052-x

Dusingize, J. C., Law, M. H., Pandeya, N., Neale, R. E., Ong, J. S., MacGregor, S., ... & Olsen, C. M. (2022). Genetically determined cutaneous nevi and risk of cancer. International Journal of Cancer, 150(6), 961-968. doi: 10.1002/ijc.33874

Farber, M. J., Heilman, E. R., & Friedman, R. J. (2012). Dysplastic nevi. Dermatologic clinics, 30(3), 389-404. doi: 10.1016/j.det.2012.04.004

Geller, A. C., Mayer, J. E., Sober, A. J., Miller, D. R., Argenziano, G., Johnson, T. M., & Swetter, S. M. (2016). Total nevi, atypical nevi, and melanoma thickness: an analysis of 566 patients at 2 US centers. JAMA dermatology, 152(4), 413-418. doi: 10.1001/jamadermatol.2016.0027

Kalmin, O. V., & Galkina, T. N. (2020). Медицинская антропология [Medical anthropology]. Высшее образование: Специалитет – Higher education: Specialitet.

Karimi, K., Lindgren, T. H., Koch, C. A., & Brodell, R. T. (2016). Obesity as a risk factor for malignant melanoma and non-melanoma skin cancer. Reviews in Endocrine and Metabolic Disorders, 17(3), 389-403. doi: 10.1007/s11154-016-9393-9

Kvaskoff, M., Bijon, A., Mesrine, S., Vilier, A., Clavel-Chapelon, F., & Boutron-Ruault, M. C. (2014). Anthropometric features and cutaneous melanoma risk: a prospective cohort study in French women. Cancer epidemiology, 38(4), 357-363. doi: 10.1016/j.canep.2014.05.008

Lahmann, P. H., Hughes, M. C. B., Williams, G. M., & Green, A. C. (2016). A prospective study of measured body size and height and risk of keratinocyte cancers and melanoma. Cancer epidemiology, 40, 119-125. doi: 10.1016/j.canep.2015.12.006

Li, X., Liang, L., Feng, Y. C. A., De Vivo, I., Giovannucci, E., Tang, J. Y., & Han, J. (2017). Height, height-related SNPs, and risk of non-melanoma skin cancer. British journal of cancer, 116(1), 134-140. doi: 10.1038/bjc.2016.366

Meyle, K. D., Gamborg, M., Sørensen, T. I., & Baker, J. L. (2017). Childhood body size and the risk of malignant melanoma in adulthood. American journal of epidemiology, 185(8), 673-680. doi: 10.1093/aje/kww128

Nikityuk, B. А., Moroz, V. M., & Nikityuk, D. B. (1998). Теория и практика интегративной антропологии. Очерки [Theory and practice of integrative anthropology. Essays]. Киев-Винница, «Здоров’я» – Kiev-Vinnitsa, “Zdorov'ya”.

Potekayev, N. N., Shuginina, Y. К., Kuzmina, Т. S., & Arutyunyan, L. S. (2011). Дерматоскопия в клинической практике. Руководство для врачей [Dermatoscopy in clinical practice. A guide for doctors]. М: МДВ, 144 – М: МDV, 144.

Reddy, K. K., Farber, M. J., Bhawan, J., Geronemus, R. G., & Rogers, G. S. (2013). Atypical (dysplastic) nevi: outcomes of surgical excision and association with melanoma. JAMA dermatology, 149(8), 928-934. doi: 10.1001/jamadermatol.2013.4440

Rezaiian, F., Davoodi, S. H., Nikooyeh, B., Ehsani, A. H., Kalayi, A., Shariatzadeh, N., ... & Neyestani, T. R. (2021). Metabolic Syndrome and Its Components are Linked with Increased Risk of Non-Melanoma Skin Cancers in Iranian Subjects: A Case-Control Study. Nutrition and Cancer, 1-9. doi: 10.1080/01635581.2021.2012581

Roh, M. R., Eliades, P., Gupta, S., & Tsao, H. (2015). Genetics of melanocytic nevi. Pigment cell & melanoma research, 28(6), 661-672. doi: 10.1111/pcmr.12412

Vena, G. A., Cassano, N., Caccavale, S., & Argenziano, G. (2019). Association between melanoma risk and height: a narrative review. Dermatology Practical & Conceptual, 9(2), 82-89. doi: 10.5826/dpc.0902a02

Viana, A. C. L., Goulart, E. M. A., Gontijo, B., & Bittencourt, F. V. (2017). A prospective study of patients with large congenital melanocytic nevi and the risk of melanoma. Anais Brasileiros de Dermatologia, 92, 200-205. doi: 10.1590/abd1806-4841.20175176

Vithayathil, M., Carter, P., Kar, S., Mason, A. M., Burgess, S., & Larsson, S. C. (2021). Body size and composition and risk of site-specific cancers in the UK Biobank and large international consortia: A mendelian randomisation study. PLoS medicine, 18(7), e1003706. doi: 10.1371/journal.pmed.1003706

Zhou, D., Wu, J., & Luo, G. (2016). Body mass index and risk of non-melanoma skin cancer: cumulative evidence from prospective studies. Scientific reports, 6(1), 1-8. doi: 10.1038/srep37691

Published
2022-06-07
How to Cite
Haddad, N. B. Y., Dmytrenko, S. V., Mateshuk-Vatseba, L. R., Khapitska, O. P., & Kyrychenko , V. I. (2022). Discriminant models of the possibility of benign nevi occurrence and features in men depending on the characteristics of anthropo-somatotypological indicators. Reports of Morphology, 28(2), 69-74. https://doi.org/10.31393/morphology-journal-2022-28(2)-10