Structural changes of rats’ aggregated lymphoid nodules of ileum in an experimental skin burn injury under the conditions of infusion by 0.9% NaCl solution


  • R.M. Matkivska
Keywords: skin burn injury, infusion therapy, 0.9% NaCl solution, structural changes, aggregated lymphoid nodules

Abstract

With the help of light and electron microscopy it was determined that the general signs of structural changes in aggregated lymphoid nodules of ileum in rats with the experimental thermal skin injury are necrosis and apoptosis of functionally different cells which occur against the background of significant changes of haemo- and lymphatic microvasculature. Necrosis and apoptosis in the case of action of 0.9% NaCl solution are superfluous and lead not only to discordance to apoptotic clearance (the rate of purification of lymphoid nodules from apoptotically degraded lymphocytes) but also to the failure to get rid of cellular necrotic detritus which serves as an additional source and a factor in the spread of inflammatory process, as well as the development of typical for burn disease intracellular and intercellular edema. Macrophagocytes in the aggregated lymphoid nodules under these conditions are in a phagocytic strain state which often ends with necrotic death. Under the conditions of infusion of 0.9% NaCl solution of burnt rats, the walls of some of the lymphatic capillaries in the aggregated lymphoid nodules surrounding each lymphoid node (juxta nodules lymphatic capillaries) is partially destroyed, or it is so refined and transparent (due to the expansion of the interendothelial spaces) that the contact between the lymph in the lumen and the intercellular connective tissue is direct and unlimited. The indicated structural changes in the lymphatic capillaries are compensatory and adaptive, considering a clear effect of prevention the intercellular edema, but they certainly have negative consequences in the form of possible uncontrolled expansion of endotoxins, biologically active substances, immune complexes, etc.

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Published
2017-10-27
How to Cite
Matkivska, R. (2017). Structural changes of rats’ aggregated lymphoid nodules of ileum in an experimental skin burn injury under the conditions of infusion by 0.9% NaCl solution. Reports of Morphology, 23(2), 231-240. Retrieved from https://morphology-journal.com/index.php/journal/article/view/54
Section
ORIGINAL INVESTIGATIONS