Rengenological features of morphogenesis of regenerate in rats with open fracture of lower jaw with osteoporosis which recepted the calcium citrate with improvement of cryoplacenta


  • A.M. Goltsev
  • O.O. Lykhytskyi
Keywords: X-ray features, fracture of the mandible, osteoporosis, cryoplacenta, calcium citrate, rats

Abstract

In the experiment, 210 male rats of the Wistar population with an open fracture of the mandible on the background of osteoporosis, with a separate subplantation of the fragments of the placenta, as well as in combination with calcium preparations, established the dynamics of the radiographic features of the regenerate morphogenesis. By X-ray in rats with fracture of the mandible on the background of osteoporosis, the phenomena of the primary tissue reaction on day 7 after the fracture transcend on 14 and 21 days in a pronounced inflammatory and destructive process, which decreases by 30 days and stops only up to 45 days. In the fracture of the mandible on the background of osteoporosis, when the drug was administered cryoplacenta, the destructive-resorptive and inflammatory reaction was less pronounced than in the control group of rats and subsided until 21-30 days, and until the 45th day, processes of consolidation of jaw fractures predominated. In the group, with the co-administration of cryoplacenta and calcium, the primary tissue reaction was manifested by weakly inflamed inflammation only for 7 days, and by 14 days there were phenomena of consolidation, which, while increasing, led to the formation of dense bony callus up to 45 days.

References

1. Barannik, N. G., Ryabokon, E. N., & Moseyko, A. A. (2010). Lechenie bolnyih s perelomami nizhney chelyusti v predelah zubnogo ryada s pomoschyu kompressionno-distraktsionnogo apparata i osteotropnyih preparatov. Zaporozhskiy meditsinskiy zhurnal, 12(3), 5-8. [in Russian].

2. Batura, I. A. (2005). Osteonnyie konstruktsii bedrennoy kosti kryis pri dlitelnom vvedenii gidrokortizona. Visnyk Bilotserkivs'koho derzhavnoho ahrarnoho universytetu, 33, 300-304. [in Russian].

3. Fan, Z. X., Lu, Y., Deng, L., Li, X. Q., Zhi, W., Li-Ling, J., … Xie, H. Q. (2012). Placenta-versus bone-marrow-derived mesenchymal cells for the repair of segmental bone defects in a rabbit model. FEBS J., 279(13), 2455-2465.

4. Furr, A. M., Schweinfurth, J. M., & May, W. L. (2006). Factors associated with long-term complications after repair of mandibular fractures. Laryngoscope, 116(3), 427-430.

5. Iryanov, Yu. M., & Silanteva, T. A. (2007). Sovremennyie predstavleniya o gistologicheskih aspektah reparativnoy regeneratsii kostnoy tkani. Kletochnyie istochniki reparativnogo osteogeneza. Geterogennost kletochnoy populyatsii v oblasti travmaticheskogo povrezhdeniya kosti. Geniy ortopedii, 2, 111-116. [in Russian].

6. Ivanov, V. P. (2014). Klinicheskaya veterinarnaya rentgenologiya. M.: Lan. [in Russian].

7. Korzh, N. A., Goridova, L. D., Deduh, N. V., & Romanenko, K. K. (2006). Reparativnaya regeneratsiya kosti: sovremennyiy vzglyad na problemu. Medikamentoznyie preparatyi, optimiziruyuschie reparativnyiy osteogenez (soobschenie 2). Ortopediya, travmatologiya i protezirovanie, 3, 85-92. [in Russian].

8. Marín-García, J., & Goldenthal, M. J. (2006). Application of Stem Cells in Cardiology: Where we are and where we are Going. Current Stem Cell Research & Therapy, 1, 1-11.

9. Oh, E. J., Kim, T. K., Shin, J. H., Choi, J. H., & Chung, H. Y. (2011). Biologic filler using human fibroblasts and placenta extracts. J. Craniofac. Surg., 22(5), 1557-1560.

10. Petrenko, V.A., Klevakin, A.Yu., Tumanov, I.A., & Chekanov, S.A. (2010). Novyie metodyi i ustroystva dlya lecheniya postradavshih s povrezhdeniyami chelyustno-litsevoy oblasti. Uralskiy meditsinskiy zhurnal, 6, 99-102. [in Russian].

11. Sanchez-Lara, P. A., & Warburton, D. (2013). Impact of stem cells in craniofacial regenerative medicine. Front. Physiol., 3, 188.

12. Semizorov, A. N. (2007). Rentgenografiya v diagnostike i lechenii perelomov kostey. Posobie dlya vrachey. M.: Vidar. [in Russian].

13. Vasilev, A. Yu., Bulanova, I. M., Malginov, H. H., Kiseleva, E. V., Chernyaev, S. E., Nikulina, O. M., … Volozhin, A. I. (2008). Vozmozhnosti tsifrovoy mikrofokusnoy rentgenografii pri otsenke reparativnoy regeneratsii kostnoy tkani v eksperimente. Vestnik rentgenologii i radiologii, 3, 21-25. [in Russian].

14. Yurchenko, T. N., & Goltsev, A. N. (2013). Platsenta: kriokonservirovanie, klinicheskoe primenenie. Harkov: FOP Brovin A.V. [in Russian].
Published
2017-10-27
How to Cite
Goltsev, A., & Lykhytskyi, O. (2017). Rengenological features of morphogenesis of regenerate in rats with open fracture of lower jaw with osteoporosis which recepted the calcium citrate with improvement of cryoplacenta. Reports of Morphology, 23(2), 248-252. Retrieved from https://morphology-journal.com/index.php/journal/article/view/57
Section
ORIGINAL INVESTIGATIONS