Participation of hydrogen sulfide system in the pathogenesis of experimental kidney failure

  • N.I. Voloshchuk
  • S.A. Konjuch
  • A.V. Melnik
Keywords: hydrogen sulfide, acute renal failure, chronic renal failure

Abstract

In experiments on rats, the involvement of the hydrogen sulfide system in the condition of the excretory organ during acute myoglobinuric and chronic renal insufficiency was established. In acute injury increasing the level of hydrogen sulfide in kidneys correlated with worsening in the functional state of the tubular and glomerular apparatus of kidneys, and decreasing of H2S, on the contrary, showed a nephroprotective effect. In chronic renal failure, an opposite pattern was revealed, while donors of hydrogen sulfide showed a protective effect, and inhibitors of its synthesis worsened the functional state of kidneys.

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References

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Published
2017-10-27
How to Cite
Voloshchuk, N., Konjuch, S., & Melnik, A. (2017). Participation of hydrogen sulfide system in the pathogenesis of experimental kidney failure. Reports of Morphology, 23(2), 252-256. Retrieved from https://morphology-journal.com/index.php/journal/article/view/58
Section
ORIGINAL INVESTIGATIONS