Participation of hydrogen sulfide system in the pathogenesis of experimental kidney failure


  • N.I. Voloshchuk
  • S.A. Konjuch
  • A.V. Melnik
Keywords: hydrogen sulfide, acute renal failure, chronic renal failure

Abstract

In experiments on rats, the involvement of the hydrogen sulfide system in the condition of the excretory organ during acute myoglobinuric and chronic renal insufficiency was established. In acute injury increasing the level of hydrogen sulfide in kidneys correlated with worsening in the functional state of the tubular and glomerular apparatus of kidneys, and decreasing of H2S, on the contrary, showed a nephroprotective effect. In chronic renal failure, an opposite pattern was revealed, while donors of hydrogen sulfide showed a protective effect, and inhibitors of its synthesis worsened the functional state of kidneys.

References

1. Voloshchuk, N. I., & Taran, I. V. (2011). Hostra toksychnist hidrohen sulfidu ta yoho vplyv na protyzapalnyi efekt dyklofenaku v eksperymenti. Medychna khimiia, 49(4), 88–91. [in Ukrainian].

2. Ioltukhivskyi, M. M. (2012). Patohenetychna rol porushen metabolizmu sirkovmisnykh aminokyslot u rozvytku tsysplatynovoi nefropatii. (Dys. kand. med. nauk). Luhanskyi medychnyi universytet, Luhansk. [in Ukrainian].

3. Pyrih, L. A., Ivanov, D. D., & Taran, O. I. (2009). Nefrolohiia: Natsionalnyi pidruchnyk. Donetsk: Vydavets Zaslavskyi O.Iu. [in Ukrainian].

4. Shtryhol, S. Yu., Lisovyi, V. M., Zupanets, I. A., Shebeko, S. K., Maslova, N. F., Hozhenko, A. I. ... Kharchenko, D. S. (2009) Metody eksperymentalnoho urazhennia nyrok dlia farmakolohichnykh doslidzhen. Metodychni rekomendatsii. Kyiv, 36. [in Ukrainian].

5. Dienemann, T., Fujii, N., Orlandi, P., Nessel, L., Furth, S. L., Hoy, W. E. … Feldman, H. I. (2016). International Network of Chronic Kidney Disease cohort studies (iNET-CKD): a global network of chronic kidney disease cohorts. BMC Nephrol. 17(1), 121. doi: 10.1186/s12882-016-0335-2.

6. Feliers, D., Lee, H. J., Kasinath, B. S. (2016). Hydrogen Sulfide in Renal Physiology and Disease. Antioxidants and Redox Signaling, 25(13), 720-731. DOI: 10.1089/ars.2015.6596

7. Francescato, D. C., Cunha, F. Q., Costa, R. S., Barbosa, J. F., Boim, M. A., Arnoni, C. P., … Coimbra, T. M. (2011). Inhibition of hydrogen sulphide formation reduces cisplatin-induced renal damage. Nephrol Dial Transplant., (2), 479-488. doi: 10.1093/ndt/gfq447

8. Lozano, R., Naghavi, M., Foreman, K., Lim, S., Shibuya, K., Aboyans, V. … Memish, Z. A. (2012). Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet, 380(9859), 2095-2128. doi: 10.1016/S0140-6736(12)61728-0.

9. Xu, C., & Jin-Song, B. (2016). The Role of Hydrogen Sulfide in Renal System. Front Pharmacol., 7, 385-392. https://doi.org/10.3389/fphar.2016.00385

10. Zaichko, N. V., Melnik, A. V., Yoltukhivskyy, M. M., Olhovskiy, A. S., & Palamarchuk, I. V. (2014). Hydrogen sulfide: metabolism, biological and medical role. Ukr. Biochem. J., 86(5), 5-25.
Published
2017-10-27
How to Cite
Voloshchuk, N., Konjuch, S., & Melnik, A. (2017). Participation of hydrogen sulfide system in the pathogenesis of experimental kidney failure. Reports of Morphology, 23(2), 252-256. Retrieved from https://morphology-journal.com/index.php/journal/article/view/58
Section
ORIGINAL INVESTIGATIONS