Transforming growth factor b as a factor in myopia development

  • D.A. Yatsenko
  • N.V. Malachkova
  • P.A. Yurchenko
  • G.P. Lyudkevich
  • T.Yu. Kukuruza
  • L.B. Furman
Keywords: TGF-b, myopia, connective tissue, sclera, extracellular matrix.

Abstract

The transforming growth factor b1 (TGP-b1) is a profibrotic cytokine belonging to the TGP-b family (TGP-b1, TGP-b2, TGP-b3), controls the synthesis and composition of the extracellular matrix (ECM), inhibits collagen degradation, is a regulator growth of scleral chondrocytes and scleral fibroblasts. TGF-b participates in changes in ECM metabolism that occur in myopia and plays a significant role in scleral remodeling processes, which significantly affects its biomechanics. As a consequence, the anterior-posterior size of the eyeball increases, which is characteristic of progressive, so-called "malignant" myopia, which manifests itself at an early age and is often associated with severe complications such as vitreous destruction, degeneration and retinal detachment, subretinal hemorrhage complicated cataract.

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Published
2017-10-27
How to Cite
Yatsenko, D., Malachkova, N., Yurchenko, P., Lyudkevich, G., Kukuruza, T., & Furman, L. (2017). Transforming growth factor b as a factor in myopia development. Reports of Morphology, 23(2), 354-357. Retrieved from https://morphology-journal.com/index.php/journal/article/view/83
Section
SCIENTIFIC REVIEWS