Transforming growth factor b as a factor in myopia development


  • D.A. Yatsenko
  • N.V. Malachkova
  • P.A. Yurchenko
  • G.P. Lyudkevich
  • T.Yu. Kukuruza
  • L.B. Furman
Keywords: TGF-b, myopia, connective tissue, sclera, extracellular matrix.

Abstract

The transforming growth factor b1 (TGP-b1) is a profibrotic cytokine belonging to the TGP-b family (TGP-b1, TGP-b2, TGP-b3), controls the synthesis and composition of the extracellular matrix (ECM), inhibits collagen degradation, is a regulator growth of scleral chondrocytes and scleral fibroblasts. TGF-b participates in changes in ECM metabolism that occur in myopia and plays a significant role in scleral remodeling processes, which significantly affects its biomechanics. As a consequence, the anterior-posterior size of the eyeball increases, which is characteristic of progressive, so-called "malignant" myopia, which manifests itself at an early age and is often associated with severe complications such as vitreous destruction, degeneration and retinal detachment, subretinal hemorrhage complicated cataract.

Published
2017-10-27
How to Cite
Yatsenko, D., Malachkova, N., Yurchenko, P., Lyudkevich, G., Kukuruza, T., & Furman, L. (2017). Transforming growth factor b as a factor in myopia development. Reports of Morphology, 23(2), 354-357. Retrieved from https://morphology-journal.com/index.php/journal/article/view/83
Section
SCIENTIFIC REVIEWS