Ultrastructural organisation of eye-ball ciliary process of rats caused by opioid having been used in different time-periods
The data regarding the changes going on in the ultrastructural organization of eye-ball ciliary process of rats caused by different time period use of opioid is given in the article. The correlation between the time line of nalbuphine administration and the profound changes of uveal tract ultrastructural organization has been established in the experiment. The research outputs serve a morphologic basis for the safe use of Nalbuphine during a two week period. A four week opioid administration has caused the changes of rat uveal tract organizational structure that can be partly compensated in two weeks after the drug discontinuation of drug. A six week opioid course of use has resulted in the irreversible destructive changes of rat uveal tract manifesing as the dedifferentiation of tissues and cells of eye-ball highly organized structures and their substitution by less differentiated elements of conjunctive tissue. The study results might be the foundation for the further search of optimal correction methods applied for changing the ultrastructure caused by a long term opioid using.