Biochemical and morphological markers of neurodegeneration in rats with hyperhomocysteinemia and its correction by vitamins, esmin and betaine


  • P. A. Yurchenko
  • A. P. Korol
  • N. V. Zaichko
  • N. A. Kaminska
Keywords: homocysteine, hydrogen sulfide, brain, neurodegeneration, esmin, vitamins, betaine

Abstract

Established biochemical and morphological markers of neurodegeneration in 88 rats with hyperhomocysteinemia (HHC) and its correction. The injection of vitamins В6, В9, В12 and polymicroelements complex Esmin provides effective elimination of homocysteine; normalizes H2S content in brain; normalizes serum level of brain-derived neurotrophic factor and neuron specificenolase; reduces neurodegenerative, neuroinflammatory and neurovascular changes in the sensomotoric cortex of rats. Betaine reduces neurotoxicity HHC, but its efficiency is lower than combination of vitamins В6, В9, В12 with Esmin.

Published
2017-10-27
How to Cite
Yurchenko, P. A., Korol, A. P., Zaichko, N. V., & Kaminska, N. A. (2017). Biochemical and morphological markers of neurodegeneration in rats with hyperhomocysteinemia and its correction by vitamins, esmin and betaine. Reports of Morphology, 21(1), 41-44. Retrieved from https://morphology-journal.com/index.php/journal/article/view/95
Section
ORIGINAL INVESTIGATIONS