@article{Gerych_Grigorenco_Horbatiuk_Binkovska_Shatkovska_2017, title={Changes of analgesic effect of sodium diclofenac upon conditions of overload of the ration with fat and experimental diabetes mellitus}, volume={22}, url={https://morphology-journal.com/index.php/journal/article/view/270}, abstractNote={<p>With the purpose of study of the influence of experimental diabetes mellitus and a high-fat diet on the analgesic effect of sodium diclofenac (substrate of cytochrome Р4502С) the rats were fed by the ration with the increased content of fat for 4 weeks (50% of energy value of the ration against 20% in the control group) and severe diabetes mellitus was induced intraperitoneally by the injection of 70 mg/kg of Streptozotocin. At this the strengthening of the analgesic effect of sodium diclofenac because of the weakening of cytochromes - Р4502С -dependent hydroxylation to inactive metabolites was observed. Such changes in pharmacodynamics should be counted upon when the necessity arises to prescribe medications - substrate СYР2С in case of obesity and diabetes mellitus.</p&gt;}, number={2}, journal={Reports of Morphology}, author={Gerych, O. K. and Grigorenco, A. P. and Horbatiuk, O. H. and Binkovska, A. M. and Shatkovska, A. S.}, year={2017}, month={Oct.}, pages={229-232} }