Pathomorpho logical changes of pancreatic tissue in experimental acute pancreatitis while using antioxidants
Abstract
The article presents the research results of the antioxidants effectiveness in experimental acute pancreatitis. We found out that conservative therapy with antioxidants promotes a significant reduction of lipid and protein peroxidation products in the blood - malondialdehyde (on 12.4%) and protein carbonyl groups (on 39.8%) (p<0.05), and reduces inhibition of glutathione peroxidase (on 15.7%) and glutathione reductase (on 11.9%) (p<0.05) of erythrocytes. It was discovered that using of antioxidant therapy reduces acinar cells destruction, necrosis of parenchyma, inflammatory infiltration of leukocytes and macrophages, atypical reactive regeneration, and increases cell proliferation, epithelial and connective tissue structures regeneration in the pancreas.